Of 6264 patients included, 25% were women, the median age was 66 years, and 61% received CRT (with or without an implantable cardioverter defibrillator). However, IVCD pattern is heterogeneous, and it is possible that QRS patterns may also respond to CRT. The primary end point was time to heart failure hospitalization (HFH) or death a secondary end point was time to all-cause death. Purpose: Response to cardiac resynchronization therapy (CRT) is well-established in patients with typical left bundle branch block (LBBB) but modest or even negative in those with intraventricular conduction delay (IVCD).
(IVCD) with coronary heart disease (CHD) death and all-cause mortality. Compared with 101.2 ± 105.3 m for IVCD patients, patients with t-LBBB performed better in a 6 min walking test, walking 211.6 ± 96.1 m (P 0.001). Appropriate discordance with ST depression and/or T-wave inversion in right precordial leads (V1-3). Bundle branch blocks and the risk of mortality in the Atherosclerosis Risk in. Left bundle branch block was diagnosed according to conventional criteria, 15, 17 namely a wide QRS, QS, or rS in lead V1. The continuous relationship between QRS duration and CRT benefit was also examined within subgroups defined by QRS morphology. RBBB: Right Bundle Branch Block V1: RSR’ pattern in V1, with (appropriate) discordant T wave changes V6: Widened, slurred S wave in V6 Associated features incude. The authors analyzed patient-level data from pivotal CRT trials (MIRACLE, MIRACLE-ICD, MIRACLE-ICD II, REVERSE, RAFT, BLOCK-HF, COMPANION, and MADIT-CRT ) using Bayesian Hierarchical Weibull survival regression models to assess CRT benefit by QRS morphology (left bundle branch block, n=4549 right bundle branch block, n=691 and intraventricular conduction delay, n=1024) and duration (with 150-ms partition). Benefit from cardiac resynchronization therapy (CRT) varies by QRS characteristics individual randomized trials are underpowered to assess benefit for relatively small subgroups.
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